Septic abortion associated with a Lippes loop.

avidly protein bound persists in the tissues. We could not implicate the subcutaneous injection techniques in the patients (Cases 3-9) who developed indurated pruritic transient lesions within hours of injection. Contact sensitization to cresols is recognized,5 and we suspect that all local and one of the systemic reactions seen in our patients resulted from hypersensitivity to the chlorocresol preservative. Intradermal skin testing with chlorocresol-preserved heparin gave immediate responses, whereas in only one (Case 1) of the tests with preservativefree heparin (Weddel) was there a reaction. We suggest that in cases of apparent heparin sensitivity treatment may be able to continue without adverse reaction after cautious challenge with chlorocresol-free heparin.